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KMID : 0378119900170010235
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Chungnam Medical Journal
1990 Volume.17 No. 1 p.235 ~ p.242
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Clinical Effect of Nizatidine on Peptic Ulcer
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Abstract
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Nizatidine is a newly introduced potent H2-receptor antagonist of acid secretion with long duration of action.
For evaluation of clinical efficacy and safety, twenty one patients with endoscopically proved thirteen gastric ulcers and eight duodenal ulcers were treated with nizatidine 300mg at bed time via per os for 6 weeks.
The results were as follows
1. The rate of complete endoscopic healing of duodenal ulcer 92.3％ and 87.5％ after 6 weeks. The overall healing rate of peptic ulcer was achieved in 89.9％ at 6 weeks.
2. Clinical symptoms disappeared in 84.6％ 92.3％ and 100％ of patients with duodenal ulcer and 75.0％, 87.5％ and 87.5％ of patients with gastric ulcer at 2, 4 and 6 weeks respectively.
3. There were not developed any symptoms and signs suggesting side effect of drug.
In conclusion, data from this study suggest that nizatidine 300mg p.o, at sleeping time is effective and safe in treatment of peptic ulcer disease, and is well tolerated on a short-term basis.
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